Assessment of Emotional Memory During Transient Global Amnesia (EMOTICTUS)

Centre Hospitalier Universitaire de Nīmes

Status: Terminated

Conditions: Amnesia, Transient Global

Treatments: Other: PET-CT examination

Study type: Observational

Funder types: Other

Identifiers

NCT04548037

NIMAO/2019-01/CH-01

Details and patient eligibility

About

There are few studies on the role played by emotions in transient global amnesia (TGA), in particular with regard to their impact on the functioning of memory. The study investigators wish to better understand the link between episodic memory, emotional state and psychogenic factors during TGA. It would be interesting to see if the patients suffering from TGA triggered by a psychological shock process emotional information differently from those whose TGA was triggered by an "organic" shock (physical effort, trauma, etc.). Finally, amnesic stroke is a good model for better understanding the function of the hippocampus, in particular of the CA1 region, in episodic memory.

Enrollment: 2 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject with no history of transient global amnesia or neurological or psychiatric pathology.
• Patients with a transient global amnesia according to the criteria of Hodges and Warlow (1990) in the acute phase (i.e. within 24 hours after the onset of the stroke), accompanied by a trusted person
• The patient must have given their free and informed consent and signed the consent form
• The patient must be a member or beneficiary of a health insurance plan

Exclusion criteria

• The subject is participating in another study, or is in a period of exclusion determined by a previous study
• The subject refuses to sign the consent
• It is impossible to give the subject informed information
• The patient is under safeguard of justice or state guardianship
• The patient is pregnant or breastfeeding
• Presence of a focal neurological pathology that may explain the symptoms, history of epilepsy or psychiatric disorders.
• Hypersensitivity to iodinated contrast media.
• Known allergy to 18-FDG.

Non-inclusion criteria concerning control subjects:

• Presence of disorders on neurological assessment
• Presence of cognitive disorders on the neuropsychological assessment (z-score <-1.65 on the RBANS or on the Stroop test).

Exclusion criteria for the target population:

• Patients will be excluded after the 1st neuropsychological assessment if episodic memory tests show complete recovery from anterograde amnesia.

Trial design

2 participants in 2 patient groups

Patients with transient global amnesia

Treatment:

Other: PET-CT examination

Healthy volunteers