Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection (Covid-Thelium)

University Hospital, Rouen

Status: Unknown

Conditions: Endothelial Dysfunction; Critically Ill; Thrombosis; Covid-19

Study type: Observational

Funder types: Other

Identifiers

NCT04357847

2020/097/OB

Details and patient eligibility

About

The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress. The endothelium is an important structure of the blood vessels and is implicated in the organ failure of many patients admitted in intensive care units. It could be affected by the virus and its alteration may explain the organ dysfunction of covid-19 ICU patients as well as the thrombotic processes frequently obstructed in this infection.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all adult patients admitted in ICU for covid-19 disease within the past 24 hrs

Exclusion criteria

• bactrial co-infection at admission
• expected death within the next 24 hrs
• pregnancy