Assessment of Er:YAG Laser-Assisted Surgical Treatment in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Clinical Trial

Wroclaw Medical University

Status: Completed

Conditions: Medication-Related Osteonecrosis of Jaw

Treatments: Procedure: irradiation with Er:YAG laser; Procedure: Tissue preparation

Study type: Interventional

Funder types: Other

Identifiers

NCT07029815

KB-27/2021

Details and patient eligibility

About

The aim of this study is assessing the effectiveness of the Er:YAG laser in relation to the use of conventional surgery in the treatment of drug-induced osteonecrosis of the jaws (MRONJ). The study compares two main treatments for advanced cases of MRONJ or cases that do not show improvement despite conservative or non-surgical treatment.

Enrollment: 65 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmed diagnosis of MRONJ

Exclusion criteria

• head and neck radiotherapy
• cases requiring hospital admission due to poor general condition

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 2 patient groups

Patients treated with the Er:YAG laser

Experimental group

Treatment:

Procedure: irradiation with Er:YAG laser

Patients treated with the conventional surgery

Active Comparator group

Treatment:

Procedure: Tissue preparation