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Assessment of Esophageal Epithelium Integrity With Mucosal Impedance

Vanderbilt University Medical Center logo

Vanderbilt University Medical Center

Status

Completed

Conditions

Non-erosive Reflux Disease (NERD)
Gastroesophageal Reflux Disease (GERD)

Treatments

Procedure: Standard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testing

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Gastroesophageal reflux disease (GERD) is a common condition affecting more than 100 million adults in the U.S., and it significantly impacts patients' quality of life while imposing billions of dollars of direct and indirect costs each year upon our healthcare system. Current diagnostic tests for GERD are highly invasive and medically inadequate, and the goal of this project is to develop a novel, minimally invasive Mucosal Impedance technique for more accurate detection of GERD while reducing costs.

Enrollment

15 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients undergoing standard of care EGD with 48-hr pH testing by BRAVO
  • Previous diagnosis of reflux
  • At least 18 years of age

Exclusion criteria

  • Those less than 18 years of age
  • Unable to give informed consent
  • Use of acid suppressive therapy within the last 10 days
  • Known history of Barrett's esophagus, gastric surgery, alcoholism, or significant motility condition

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

15 participants in 2 patient groups

GERD
Other group
Description:
Those who have abnormal pH and abnormal esophageal mucosa and those who have abnormal pH and normal esophageal mucosa and are scheduled for standard of care esophagogastroduodenoscopy (EGD) with mucosal impedance testing
Treatment:
Procedure: Standard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testing
non-GERD
Other group
Description:
Those who have normal pH and normal esophageal mucosa and are scheduled for standard of care esophagogastroduodenoscopy (EGD) with mucosal impedance testing
Treatment:
Procedure: Standard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testing

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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