Assessment of Functional and Symptom Outcomes for Survivors of Paranasal Sinus, Nasopharyngeal and Skull Base Tumors

M.D. Anderson Cancer Center

Status: Enrolling

Conditions: Tumors

Treatments: Behavioral: Standard of Care

Study type: Observational

Funder types: Other

Identifiers

NCT05733091

PA18-0969

NCI-2023-01436 (Other Identifier)

Details and patient eligibility

About

To learn about the symptoms and changes our patients experience while receiving treatment for sinonasal or nasopharyngeal cancer

Full description

Objectives:

• To estimate the prevalence and severity of adverse and functional outcomes in survivors of benign and malignant paranasal sinus, nasopharynx and skull base tumors.
• To estimate the prevalence of health promotion behaviors during skull base tumor survivorship
• To identify possible mediators or predictors of survivorship outcomes and health behaviors in survivors of skull base tumors.
• To develop a database of demographic, clinicopathologic, recurrence, survival, functional and patient reported outcomes (PROS) for patients with benign and malignant paranasal sinus, nasopharyngeal and skull base tumors.
• To assess the utility and limitations of PROs in evaluating functional impairments and symptom burden in skull base patients.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Previously untreated patients with or suspected to have sinonasal malignancy or nasopharyngeal malignancy diagnosis based on either outside pathology report or MD Anderson pathology report.
2. Age ≥ 18 years
3. Plan to obtain the majority of treatment at MDACC including surgery and radiotherapy
4. Ability to understand and willingness to sign written informed consent

Exclusion criteria

1. History of the previous solid or liquid malignancies, apart from skin cancers treated with local therapy.
2. Existing neurocognitive impairment that is not the result of sinonasal and nasopharyngeal cancers or is treatment.
3. Previous treatment for sinonasal or nasopharyngeal carcinomas, apart from biopsy.