Assessment of GARP Expression in Acute and Chronic Coronary Syndrome (GARP-CS)

Université Catholique de Louvain

Status: Not yet enrolling

Conditions: Atheroma; Heart

Treatments: Biological: Arterial blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT07384910

GARP-CS

Details and patient eligibility

About

The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.

Enrollment: 600 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Older than 18 years
• Able to give informed consent
• Undergoing coronary angiography.

Exclusion criteria

• Patients younger than 18 years
• Unable to give consent
• Pregnancy
• Dialysis

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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600 participants in 3 patient groups

Acute coronary syndrome

Experimental group

Description:

This arm includes patients undergoing coronary angiography with a final diagnostic of acute coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.

Treatment:

Biological: Arterial blood sample

Chronic coronary syndrome

Experimental group

Description:

This arm includes patients undergoing coronary angiography with a final diagnostic of chronic coronary syndrome. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.

Treatment:

Biological: Arterial blood sample

Control

Experimental group

Description:

This arm includes patients undergoing coronary angiography with a final diagnostic of non significant coronary disease. The intervention administered is an arterial blood sample from the sheath at the beginning of the examination.

Treatment:

Biological: Arterial blood sample