Assessment of Gastric Motility on Funtional Dyspepsia and Joint Hypermobility Syndrome

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Functional Dyspepsia; Joint Hypermobility Syndrome

Treatments: Other: No intervention: assessment of GI function

Study type: Observational

Funder types: Other

Identifiers

NCT04279990

S56804

Details and patient eligibility

About

Functional dyspepsia (FD) is defined as the presence of gastroduodenal symptoms in the absence of organic disease that is likely to explain the symptoms. Joint hypermobility (JH) refers to the increased passive or active movement of a joint beyond its normal range. Recent reports have highlighted the co-existence of FD with Ehlers-Danlos syndrome type III or hypermobility type (EDSIII). The association between FD and EDS III, and the underlying pathophysiological alterations, are poorly understood. We hypothesised that EDS III might influence gastroduodenal sensorimotor function, resulting in dyspeptic symptoms. Therefore, the aim of this study is to explore the impact of EDS III on gastric motility, nutrient tolerance and dyspeptic symptoms in patients with functional dyspepsia.Our aim is to study the prevalence of EDSIII in FD compared to healthy subjects (HS) and to study the impact of co-existing EDSIII on gastric motility, nutrient tolerance and dyspeptic symptoms in FD.

Enrollment: 54 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with PDS diagnosis as per Rome III by Rome III questionnaire

Exclusion criteria

Patients are excluded from the study if any of the following criteria are met:

• Females who are pregnant or lactating.
• Patients who are H. Pylori positive
• Patients with confirmed gastro-intestinal disease, with former digestive surgery affecting upper gut motility, a concomitant disease responsible for digestive symptoms
• Patients presenting with predominant symptoms of irritable bowel syndrome (IBS), CIN or GERD.

Trial design

54 participants in 3 patient groups

Functional dyspepsia patients with JHS

Description:

Patients with functional dyspepsia as defined by the Rome III criteria and joint hypermobility syndrome as defined by the Beighton Hypermobility criteria.

Treatment:

Other: No intervention: assessment of GI function

Functional dyspepsia patients without JHS

Description:

Patients with functional dyspepsia as defined by the Rome III criteria and WITHOUT joint hypermobility syndrome as defined by the Beighton Hypermobility criteria.

Treatment:

Other: No intervention: assessment of GI function

Healthy subjects

Description:

Healthy subjects with no gastrointestinal diseases including no functional dyspepsia

Treatment:

Other: No intervention: assessment of GI function