Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas

Memorial Sloan Kettering Cancer Center (MSK)

Status: Enrolling

Conditions: Osteosarcoma; Bone Neoplasm; Chondrosarcoma; Ewing's Sarcoma; Bone Sarcoma; Osseous Sarcoma

Treatments: Behavioral: Toronto Extremity Salvage Score; Behavioral: Musculoskeletal Tumor Society Score; Behavioral: Timed Get Up and Go Test; Diagnostic Test: Range of Motion; Diagnostic Test: Weight Bearing for lower extremities only; Diagnostic Test: Orthogonal Radiographs

Study type: Observational

Funder types: Other

Identifiers

NCT03442465

18-014

Details and patient eligibility

About

The purpose of this study is to look at the amount of function that returns in participants that have reconstruction with bone graft or artificial device and in participants who have tumor surgery plus regenerative osseous surgery.

The study will look at the level of function for a period of 3 years after the surgery. Another purpose of this study is to look at how well the bone heals in participants undergoing regenerative surgery

Enrollment: 300 estimated patients

Sex: All

Ages: 4+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients undergoing reconstructive surgery for neoplasms involving bone on the orthopaedic surgery service at MSK
• Current or prior history of primary neoplasms involving osseous structures, including all subtypes
• Confirmation of diagnosis that has been performed by the MSK's Department of Pathology via direct review of tissue/slides
• Patients must read and understand English
• Age >/=4
• Patients must read and understand English

Exclusion criteria

• Patients that weight <17 kilograms

Trial design

300 participants in 2 patient groups

Regenerative Osseous Surgery

Description:

Participants undergoing osseous reconstructive surgery (RegOS) for bone neoplasm. Study visits for post-op assessments will be annually after month-36.

Treatment:

Diagnostic Test: Orthogonal Radiographs

Diagnostic Test: Weight Bearing for lower extremities only

Diagnostic Test: Range of Motion

Behavioral: Timed Get Up and Go Test

Behavioral: Musculoskeletal Tumor Society Score

Behavioral: Toronto Extremity Salvage Score

Other Reconstructive Surgery

Description:

Participants undergoing other reconstructive surgery for bone neoplasm. Study visits for post-op assessments will be annually after month-36.

Treatment:

Diagnostic Test: Orthogonal Radiographs

Diagnostic Test: Weight Bearing for lower extremities only

Diagnostic Test: Range of Motion

Behavioral: Timed Get Up and Go Test

Behavioral: Musculoskeletal Tumor Society Score

Behavioral: Toronto Extremity Salvage Score