Assessment of Hemodynamic Response in Cardiopulmonary Bypass Graft After Cardiopulmonary Bypass Using Transesophegeal Echocardiography

Federal University of Juiz de Fora

Status and phase: Completed; Phase 4

Conditions: Cardiopulmonary Bypass Graft

Treatments: Drug: epinephrine and levosimendan

Study type: Interventional

Funder types: Other

Identifiers

NCT01616069

0362/14-12-2011

Details and patient eligibility

About

This is a double blind randomization study, assessing hemodynamic response in patients who underwent a cardiopulmonary bypass graft (CABG) with cardiopulmonary bypass (CPB) using intraoperative trasnesophageal echocardiography (TEE) to know what inotropic drug will be batter to improve the heart function. Epinephrine, milrinone, dobutamine and levosimendan will be assessment.

Enrollment: 81 patients

Sex: All

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sinusal ritmus
• EF > 35%
• Elective CABG surgery

Exclusion criteria

• No accept
• Severe valvular regurgitation or stenoses
• Chest pain
• Cardiogenic shock

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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81 participants in 2 patient groups

epinephrine

Active Comparator group

Description:

Assessment of systolic and diastolic heart function during CABAG with CPB with levosimendan using TEE.

Treatment:

Drug: epinephrine and levosimendan

levosimendan

Active Comparator group

Description:

Assessment of systolic and diastolic heart function during CABAG with CPB with epinephrine using TEE.

Treatment:

Drug: epinephrine and levosimendan