Assessment of Hemostatic Profile in Liver Cirrhosis

Goethe University

Status: Completed

Conditions: Coagulation Disorder

Treatments: Other: Assessment of hemostatic profile

Study type: Observational

Funder types: Other

Identifiers

NCT04265508

195/17

Details and patient eligibility

About

Our study included both in- and outpatients suffering from liver cirrhosis attending the out- and inpatient care of the department of hepatology. Demographic and biochemical data as well as medical history including cause of liver cirrhosis, end stage kidney failure and medication with anticoagulants were recorded. To assess the hemostatic profile, platelet function was analyzed by multiple electrode aggregometry (MEA) using Multiplate (ADP-, ASPI- and TRAP-test) and thrombelastometry using ROTEM (EXTEM, INTEM, FIBTEM).

Enrollment: 67 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• liver cirrhosis
• age of ≥ 18 years
• platelet count of at least 70 / nl

Exclusion criteria

• transfusion of platelet concentrate three weeks prior to inclusion
• pregnancy
• age < 18 years
• missing informed consent

Trial design

67 participants in 2 patient groups

Low MELD score

Description:

MELD score of 6 - 11

Treatment:

Other: Assessment of hemostatic profile

High MELD score

Description:

MELD score of ≥ 17

Treatment:

Other: Assessment of hemostatic profile