Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

Sohag University

Status: Enrolling

Conditions: Vitiligo

Treatments: Device: Punch Biopsy 5mm

Study type: Interventional

Funder types: Other

Identifiers

NCT06410898

Soh-Med-24-04-014MS

Details and patient eligibility

About

The present study will aim to evaluate:

1. The presence of Hypoxia Inducible Factor in vitiligo patient
2. Defect of Autophagy Related Genes in vitiligo patient
3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult >18 years
• With non segmental vitiligo
• A group of participants will be included as a control group

Exclusion criteria

• Pregnancy
• Patient with chronic inflammatory skin disorders
• patient on anti-oxidant or anti-inflammatory drugs
• patient on topical or systemic treatment for vitiligo in last 4 weeks
• patients with other autoimmune diseases
• patients with diabetes mellitus

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

skin biopsy from vitiligo lesion in vitiligo patient

Active Comparator group

Description:

punch biopsy 5mm from vitiligo patch in vitiligo patient

Treatment:

Device: Punch Biopsy 5mm

skin biopsy from normal skin in vitiligo patient

Active Comparator group

Description:

punch biopsy 5mm from normal skin patch in vitiligo patient

Treatment:

Device: Punch Biopsy 5mm

skin biopsy from normal skin in normal person

Active Comparator group

Description:

punch biopsy 5mm from normal skin patch in normal person

Treatment:

Device: Punch Biopsy 5mm