Assessment of International Normalized Ratio (INR) Prolongation in Patients Treated Simultaneously With Warfarin and Cephalosporins

Clalit Health Services

Status: Completed

Conditions: Pulmonary Embolism; Atrial Fibrillation; Venous Thrombosis

Study type: Observational

Funder types: Other

Identifiers

NCT01857050

MMC130210-12CTIL

Details and patient eligibility

About

Many drug interactions with Warfarin are well documented in the literature, including interactions with a variety of antibiotics. However,in mamy cases it is difficult to predict when the interaction remains theoretical and when it becomes clinically significant and will be reflected in the individual patient. This study's aim is to identify and characterize related conditions (including comorbidities, laboratory test results and other parameters related to the patient)that might be predictors for drug interactions turning from theoretical to clinically significant.

Enrollment: 236 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 and over
• Patients treated with a combination of Warfarin and Cephalosporins
• Patients who were hospitalized in the department of internal medicine
• Patients who were treated with Warfarin without Cefalosporins

Exclusion criteria

• Patients on Warfarin who did not actually receive the drug during their hospitalization
• Patients whose medical records were not accessible or didn't contain full data