Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging

Assiut University

Status: Unknown

Conditions: Mediastinal Tumor

Treatments: Radiation: MRI diffusion

Study type: Observational

Funder types: Other

Identifiers

NCT03214341

MRIML

Details and patient eligibility

About

Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy which is essential for treatment planning as well as for prognosis

Full description

Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy is essential for treatment planning as well as for prognosis .

MRI presents valuable diagnostic information in assessing the mediastinum. In addition, special applications have been developed over recent years diffusion-weighted magnetic resonance imaging is one such technique The advent of echo-planar imaging technique has rendered diffusion weighted imaging of the abdomen and thoracic cavity possible .

Quantitative assessment of the mediastinal mass is possible by calculation of apparent diffusion co-efficient value ,which is related to the proportion of extracellular and intracellular component.

The apparent diffusion co-efficient is inversely correlated with tissue cellularity. It is lower in viable tumor tissue with densely packed diffusion-hindering obstacles than in tissue with less densely packed obstacles such as tumor necrosis and benign tissue .

Enrollment: 24 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any age groups
• diagnosis of mediastinal mass (by Multislice Computed Tomography).

Exclusion criteria

• chemotherapy radiotherapy.
• thoracic surgery.
• cystic mass .
• mass with large amount of necrosis or calcification.
• contraindication of MRI (e.g. pacemakers , claustrophobia).