Assessment of Metabolic Response in Critically Ill Patients With Acute Renal Failure

Vanderbilt University

Status and phase

Terminated

Phase 2

Conditions

Acute Renal Failure

Treatments

Drug: TPN nutritional supplement

Study type

Interventional

Funder types

Other

Identifiers

NCT00179166

30941

Details and patient eligibility

About

We hypothesize that a nutritional supplementation with higher than standard protein content (2.0 gm/Kg/day vs 1.4 gm/Kg/day) will result in improved whole-body net protein balance when administered to critically ill patients with acute renal failure (ARF).

Enrollment

3 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adults ≥ 18 years of age admitted to the intensive care unit
New onset acute renal failure (ARF) or ARF superimposed on chronic kidney disease
ARF will be defined by a sustained (over 24 hours) increase in serum creatinine > 0.5 mg/dl from baseline
Patients will be recruited for the study within 3-5 days following establishment of ARF

Exclusion criteria

Institutionalized patient
Previous kidney transplant
Pregnancy
Unable to obtain consent from subject or legally recognized representative
ARF from urinary tract obstruction or a volume responsive pre-renal state.
Liver Failure
Recent cerebrovascular accident (CVA)
Coagulopathy defined as: Platelets < 50, PT > 20, INR > 2.0 if the patient requires the placement of an arterial or venous catheter; if the patient does not require the placement of an arterial or venous catheter for the study, coagulopathy will not be a basis for exclusion.
Life expectancy < 48 hours