Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft Versus Bovine Graft Only on Ridge Preservation.

Cairo University (CU)

Status: Not yet enrolling

Conditions: Tooth Mobility

Treatments: Procedure: microfragmented adipose tissue loaded on bovine graft

Study type: Interventional

Funder types: Other

Identifiers

NCT06457867

microfragmented adipose tissue

Details and patient eligibility

About

Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by Radiographic and Histomorphometry) utilizing microfragmented adipose tissue loaded on bovine graft versus bovine graft only for maxillary posterior ridge preservation.

Full description

All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on bovine graft will be utilized for the study group and bovine raft only for the control group.

After 6 months, patients will be evaluated histomorphometrically via core biopsy at the time of implant placement and radiographically via assessment of ridge height on CBCT.

Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height from base line (1week) to 6 months postoperatively.

Enrollment: 22 estimated patients

Sex: All

Ages: 21 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium.

  • Age group: above 21 years
  • Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.

Exclusion criteria

• General contraindications to implant surgery.

  • Subjected to irradiation in the head and neck area less than 1 year before implantation.
  • Poor oral hygiene and motivation.
  • Severe bruxism or clenching.
  • Systemic, immunologic, or debilitating diseases that could affect normal bone healing & local pathosis.
  • Treated or under treatment of intravenous amino bisphosphonates.
  • Active infection or severe inflammation in the area intended for implant placement.
  • Patients participating in other studies if the present protocol could not be properly followed.
  • Heavy smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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22 participants in 2 patient groups

microfragmented adipose tissue

Experimental group

Description:

microfragmented adipose tissue loaded on bovine graft on ridge preservation

Treatment:

Procedure: microfragmented adipose tissue loaded on bovine graft

bovine graft

Active Comparator group

Description:

bovine graft only on ridge preservation

Treatment:

Procedure: microfragmented adipose tissue loaded on bovine graft