Assessment of Myocardial Injury in Simultaneous Pancreas and Kidney Transplantation (AMI-SPK)

Tianjin First Central Hospital

Status: Unknown

Conditions: Diabetic Cardiomyopathy; Simultaneous Pancreas-kidney Transplantation

Treatments: Radiation: cardiac magnetic resonance(CMR) T2 mapping

Study type: Observational

Funder types: Other

Identifiers

NCT03904485

2019N020KY

Details and patient eligibility

About

Diabetic cardiomyopathy( DCM) is a major complication of diabetes and is a common cardiovascular complication independent of coronary artery disease and hypertension．Trial to assess of myocardial injury in recipients of simultaneous pancreas and kidney transplantation by nuclear magnetic T２ mapping technology.

Full description

1. Evaluate the changes of myocardial injury before and after SPK by cardiac magnetic resonance imaging (CMR),
2. Evaluate the value of SPK in the repair of myocardial injury by comparing with the single renal transplant in recipients with diabetic nephropathy.

Enrollment: 50 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients with type 2 diabetes were treated with SPK; 2.No definite history of cardiovascular diseases (such as congenital heart disease, coronary heart disease, cardiomyopathy or valvular heart disease, etc.); 3. Preoperative hemodialysis 4. No history of heart failure

Exclusion criteria

1. Contraindications in cardiac magnetic resonance imaging；2.poorly controlled hypertension；3.CMR examination revealed marked hypertrophy of the left ventricular myocardium

Trial design

50 participants in 2 patient groups

SPKT

Description:

patients with end-stage diabetic nephropathy got simultaneous pancreas-kidney transplantation

Treatment:

Radiation: cardiac magnetic resonance(CMR) T2 mapping

RT

Description:

patients with end-stage diabetic nephropathy got single kidney transplantation

Treatment:

Radiation: cardiac magnetic resonance(CMR) T2 mapping