Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG

St. Petersburg State Pavlov Medical University

Status: Completed

Conditions: Coronary Artery Disease; Ischemic Heart Disease; CABG; Ischemic Reperfusion Injury

Treatments: Procedure: On-Pump CABG.; Procedure: Off-Pump CABG.; Procedure: BH-CABG MSC.

Study type: Observational

Funder types: Other

Identifiers

NCT03050489

AMIRI-CABG 03/17-11

Details and patient eligibility

About

Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG.

Full description

Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG is monitored by intraoperative measurement of serum level of myeloperoxidase before sternotomy and after sternal closure.

Enrollment: 336 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ischemic heart disease

Exclusion criteria

• valve disease
• diabetes millitus

Trial design

336 participants in 3 patient groups

On-Pump CABG

Description:

Patients with coronary artery bypass graft (CABG) surgery performed with cardiopulmonary bypass.

Treatment:

Procedure: On-Pump CABG.

Off-Pump CABG

Description:

Patients with coronary artery bypass graft (CABG) surgery performed without cardiopulmonary bypass.

Treatment:

Procedure: Off-Pump CABG.

BH-CABG MSC.

Description:

Patients with coronary artery bypass graft (CABG) surgery performed on beating heart with mechanical support of circulation.

Treatment:

Procedure: BH-CABG MSC.