Assessment of Nipple Sparing Mastectomy as a Treatment Option for Breast Cancer

Alexandria University

Status: Completed

Conditions: Breast Cancer

Treatments: Procedure: nipple sparing mastectomy

Study type: Observational

Funder types: Other

Identifiers

NCT04640454

13-27-10

Details and patient eligibility

About

Nipple-sparing mastectomy (NSM) with immediate breast reconstruction (IBR) is a form of mastectomy that achieves optimal disease control and facilitates reconstruction. The study aimed to assess the oncological safety and aesthetic outcomes of nipple-sparing mastectomy and immediate breast reconstruction.

35 female patients with breast cancer were included in the study. The investigators categorized the incisions into radial, inframammary, and periareolar incisions with planned reconstruction types; direct to implant (DTI), transversus rectus abdominis myocutaneous (TRAM) flap, latissimus dorsi myocutaneous (LD) flap, or LD with implant.

Enrollment: 35 patients

Sex: Female

Ages: 28 to 68 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of ductal in situ carcinoma or infiltrating ductal carcinoma with a tumor diameter up to 3 cm
• Distance of the tumor from the nipple ≥ 2 cm
• Cancer or microcalcifications not localized in the central field.
• No blood secretions or other (nipple-areola complex) NAC disturbances
• Absence of skin involvement
• Indication to mastectomy for multifocal or diffuse microcalcifications
• Negative intraoperative assessment of NAC-bottom

Exclusion criteria

• Tumor or microcalcifications localized in the central quadrant or in the retroareolar region
• Blood secretions or other NAC alterations
• Positive intraoperative assessment of NAC-bottom
• Inflammatory carcinoma
• Paget's disease of the nipple