Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia

Marmara University

Status: Completed

Conditions: Erosion, Dental Enamel; Quality of Life; Primary Ciliary Dyskinesia; Caries,Dental; Saliva Altered

Treatments: Diagnostic Test: Pediatric Oral Health Quality of Life; Diagnostic Test: physical and chemical methods; Diagnostic Test: biochemical methods; Diagnostic Test: Oral Findings

Study type: Observational

Funder types: Other

Identifiers

NCT06618209

09.2023.305

Details and patient eligibility

About

The aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with Primary Ciliary Dyskinesia (PCD) with healthy children

Full description

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder that affects the function of cilia, which are tiny hair-like structures responsible for moving mucus and other substances in the respiratory tract and other parts of the body. Dysfunctional cilia lead to impaired mucociliary clearance, resulting in chronic respiratory infections, sinusitis, and bronchiectasis. PCD can also cause situs inversus, where internal organs are mirrored from their normal positions, and other complications like chronic otitis media and fertility issues. Early diagnosis and management are crucial to prevent progressive lung damage and improve the quality of life in affected individuals.

This study aims to compare the oral and dental health of children diagnosed with Primary Ciliary Dyskinesia (PCD) to that of healthy controls. The study includes assessments of dental caries (using DMFT, dmft, and ICDAS II indices), salivary parameters (flow rate, pH, buffering capacity, oxidant-antioxidant levels, tissue factor activity), enamel defects (using the Modified Developmental Defects of Enamel Index), and oral hygiene (gingival and plaque indices). The Pediatric Oral Health-Related Quality of Life (POQL) scale will be used to evaluate the impact of oral health on quality of life.

Enrollment: 160 patients

Sex: All

Ages: 6 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Not having any systemic disease.
• Not being on any regular medication.

Exclusion criteria

• Having any systemic disease.
• Being on any regular medication.

Trial design

160 participants in 4 patient groups

Children with primary ciliary dyskinesia group

Description:

It is a group of patients between the ages of 6 and 17 who have recently been diagnosed with primary ciliary dyskinesia

Treatment:

Diagnostic Test: Oral Findings

Diagnostic Test: biochemical methods

Diagnostic Test: physical and chemical methods

Diagnostic Test: Pediatric Oral Health Quality of Life

healthy patient group

Description:

Healthy children aged between 6 and 17 years, with no systemic diseases and not taking any regular medications.

Treatment:

Diagnostic Test: Oral Findings

Diagnostic Test: biochemical methods

Diagnostic Test: physical and chemical methods

Diagnostic Test: Pediatric Oral Health Quality of Life

Parents of children with Primary Ciliary Dyskinesia group

Description:

Parents of children aged 6-17 with Primary Ciliary Dyskinesia

Treatment:

Diagnostic Test: Pediatric Oral Health Quality of Life

Parents of healthy children group

Description:

Parents of children aged 6-17 healthy children

Treatment:

Diagnostic Test: Pediatric Oral Health Quality of Life