Assessment of PENG Block Analgesia Versus Intra-articular Infiltration in Hip Prosthesis Surgery (API)

GCS Ramsay Santé pour l'Enseignement et la Recherche

Status: Completed

Conditions: Analgesia

Treatments: Procedure: Intra-articular infiltration with lidocaine hydrochloride; Procedure: PENG Block with lidocaine hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT06675916

2021-A00539-32

Details and patient eligibility

About

After hip arthroplasty, pain intensity is maximum within the first 6 hours and is then estimated to last between 36 and 72 hours.

Pain management (analgesia) after hip prosthetic surgery remains a challenge. A bad analgesic treatment can result in delay in mobilization/ambulation and thus increase duration of patient's stay which can have a significant economic impact.

The different recognized analgesia techniques (intra-articular infiltration and peripheral nerve blocks) are effective but have shown certain limits.

A new peripheral nerve block, the PENG block has shown very encouraging results on postoperative analgesia quality.

In this context, this research is based on the hypothesis that ultrasound-guided PENG block could provide more effective analgesia than intra-articular infiltration during mini-invasive anterior hip prosthesis surgery.

Full description

Each year, around140 000 patients undergo total hip arthroplasty. After hip arthroplasty, pain intensity is maximum within the first 6 hours and is then estimated to last between 36 and 72 hours. However, more and more patients want to no longer suffer after surgery. Indeed, if postoperative pain is moderate at rest, it is often exacerbated by movement. Severe pain occurs in 50 % of patients at rest and in 70% of patients during mobilization.

Pain management (analgesia) after hip prosthetic surgery remains a challenge for the anesthesiologist. A bad analgesic treatment can result in delay in mobilization/ambulation and thus increase duration of patient's stay which can have a significant economic impact. Quality analgesia is therefore essential to reduce post-operative pain and improve functional rehabilitation in patients undergoing hip surgery.

The different recognized analgesia techniques (intra-articular infiltration and peripheral nerve blocks) are effective but have shown certain limits: rapid and non-lasting effect of analgesia or poor targeting of all nerves of hip joint.

A new peripheral nerve block, the PENG block, identified during a recent anatomical study in 2018, has shown very encouraging results on postoperative analgesia quality on several small series of patients.

In this context, this research is based on the hypothesis that ultrasound-guided PENG block could provide more effective analgesia than intra-articular infiltration and therefore reduce the intraoperative opioid consumption during mini-invasive anterior hip prosthesis surgery under general anaesthesia.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient, male or female, over 18 years old.
• Patient scheduled for hip prosthesis placement via the anterior approach

Exclusion criteria

• Patient with local anesthesia contraindication.
• Patient with a high level of dependency, defined by level 1 or 2 of Iso Ressources Group (GIR).

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

PENG block

Experimental group

Description:

Total hip prosthesis with infiltration of lidocaine hydrochloride by ultrasound-guided PENG block

Treatment:

Procedure: PENG Block with lidocaine hydrochloride

Intra-articular infiltration

Active Comparator group

Description:

Total hip prosthesis with intra-articular infiltration of lidocaine hydrochloride

Treatment:

Procedure: Intra-articular infiltration with lidocaine hydrochloride