Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections (EVALYMPH)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Cancer of the Digestive System; Thoracic Diseases

Treatments: Other: Collection of plasma cell rate

Study type: Observational

Funder types: Other

Identifiers

NCT02799251

1600010

Details and patient eligibility

About

Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery.

Full description

Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis.

The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery. It is a multicenter French cohort study. Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery before surgery (day-0) as well 1, 3, 5 and 8 days after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.

Enrollment: 1,125 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient undergoing digestive or thoracic cancer surgery under general anesthesia.

Exclusion criteria

• pregnant women,
• malignant blood disease,
• allograft patient,
• preoperative sepsis or preoperative systemic inflammatory response syndrome.

Trial design

1,125 participants in 1 patient group

Collection of plasma cell rate

Description:

Post operative infections and their association with lymphopenia are assessed in this study for patients over 18 years of age undergoing digestive or thoracic cancer surgery under general anesthesia.

Treatment:

Other: Collection of plasma cell rate