Assessment of Potential Interactions Between Cocaine and Tolcapone - 1

National Institutes of Health (NIH)

Status and phase: Unknown; Phase 1

Conditions: Cocaine-Related Disorders

Treatments: Drug: Tolcapone

Study type: Interventional

Funder types: NIH

Identifiers

NCT00033059

NIDA-CTO-0003-1

Details and patient eligibility

About

The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.

Full description

Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence

Exclusion criteria

Additional criteria available during screening at the site