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Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

M

Minia University

Status

Unknown

Conditions

Apical Periodontitis

Treatments

Other: Method

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

Enrollment

20 estimated patients

Sex

All

Ages

11 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients with mature teeth.
  • Patients with periapical periodontitis.
  • Maxillary anterior teeth only will be involved.
  • Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
  • Patients who will agree to the consent and will commit to follow up period.

Exclusion criteria

  • Patients with immature roots.
  • Patients with any systemic disease that may affect normal healing.
  • Patients with swelling.
  • Pregnant females.
  • Patients who could/would not participate in a 1 year follow up.
  • Patients with fistula.
  • Patients with old age.
  • Teeth with periodontal involvement.
  • Teeth with vertical root fractures.
  • Unrestorable teeth.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

20 participants in 2 patient groups

Blood clotting protocol for pulp regeneration
Active Comparator group
Description:
pulp regeneration for mature teeth using blood clotting protocol
Treatment:
Other: Method
platelet rich fibrin for pulp regeneration
Experimental group
Description:
pulp regeneration for mature teeth using platelet rich fibrin (PRF)
Treatment:
Other: Method

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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