Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Minia University

Status: Unknown

Conditions: Apical Periodontitis

Treatments: Other: Method

Study type: Interventional

Funder types: Other

Identifiers

NCT04158232

306

Details and patient eligibility

About

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

Enrollment: 20 estimated patients

Sex: All

Ages: 11 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with mature teeth.
• Patients with periapical periodontitis.
• Maxillary anterior teeth only will be involved.
• Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
• Patients who will agree to the consent and will commit to follow up period.

Exclusion criteria

• Patients with immature roots.
• Patients with any systemic disease that may affect normal healing.
• Patients with swelling.
• Pregnant females.
• Patients who could/would not participate in a 1 year follow up.
• Patients with fistula.
• Patients with old age.
• Teeth with periodontal involvement.
• Teeth with vertical root fractures.
• Unrestorable teeth.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Blood clotting protocol for pulp regeneration

Active Comparator group

Description:

pulp regeneration for mature teeth using blood clotting protocol

Treatment:

Other: Method

platelet rich fibrin for pulp regeneration

Experimental group

Description:

pulp regeneration for mature teeth using platelet rich fibrin (PRF)

Treatment:

Other: Method