Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty

Assiut University

Status: Not yet enrolling

Conditions: Mitral Stenosis

Study type: Observational

Funder types: Other

Identifiers

NCT06067815

Mitral stenosis PTMC

Details and patient eligibility

About

To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function

Full description

In patients with mitral valve stenosis, right ventricular failure may develop either by the rheumatic process directly or through hemodynamic alterations resulting from pulmonary vascular changes.

Right ventricular (RV) function plays an important role in development of clinical symptoms and prognosis in patients with mitral stenosis (MS).This is primarily affected by hemodynamic effects on RV due to pulmonary hypertension(PH).

In the last two decades, Percutaneous Transluminal Mitral Commissurotomy (PTMC) has become the treatment of choice for patients with symptomatic rheumatic MS . Using this method,Mitral Valve Area (MVA) can be increased, which can improve the hemodynamic and clinical features of patients with MS .

RV functional assessment is difficult and not done routinely because of its complex anatomy and high load dependence.

Different modalitis are used to assess RV function as Tissue Doppler and two-dimensional (2D) speckle tracking method has been used to quantify strain for assessment Myocardial strain is a measure of tissue deformation, which is expressed as a percentage change.

Enrollment: 30 estimated patients

Sex: All

Ages: 16 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with isolated mitral stenosis (except those with mild mitral regurgitation and are candidate for PTMC by 2D Echo evaluation).

  • Patient with normal left ventricular EF.
  • patient with sinus rhythm or AF
  • patient with any degree of pulmonary HTN

Exclusion criteria

• Patient with another valve lesion or more than mild mitral regurgitation.
• Patient with impaired cardiac function.
• patient with coronary arteries disease
• Mitral stenosis of other etiology than rheumatic origin.