Assessment of Rituximab's Immunomodulatory Synovial Effects (The ARISE Study)

University of California San Diego logo

University of California San Diego

Status and phase

Completed
Phase 2

Conditions

Rheumatoid Arthritis

Treatments

Drug: rituximab

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT00147966
041569

Details and patient eligibility

About

Using repeated arthroscopic biopsies of patients with rheumatoid arthritis, the researchers will assess changes in the immune response that occur as a result of treatment with rituximab.

Full description

Using repeated arthroscopic biopsies of patients with rheumatoid arthritis, the researchers will assess changes in the immune response that occur after treatment with rituximab.

Enrollment

24 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Active rheumatoid arthritis
  • Use of concomitant methotrexate

Exclusion criteria

  • Use of disease-modifying anti-rheumatic drugs (DMARDs)/biologics other than methotrexate
  • Serious medical conditions that would preclude the use of the treating agent

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

24 participants in 1 patient group

ritxumab
Experimental group
Description:
all patients get treatment
Treatment:
Drug: rituximab

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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