Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

Benha University

Status: Completed

Conditions: Infertility, Male; Varicocele

Treatments: Procedure: Varicocelectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT04856579

RC-5-4-2021

Details and patient eligibility

About

Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.

Full description

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele

Enrollment: 30 patients

Sex: Male

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Infertile men
• Varicocele
• Poor sperm parameters

Exclusion criteria

• Men with systemic diseases
• Infertile men due to other causes than varicocele

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Varicocelectomy

Other group

Description:

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Treatment:

Procedure: Varicocelectomy