Assessment of Serum Levels of Adenosine Deaminase and Immunoglobulin E in Patients With Chronic Spontaneous Urticaria

Sohag University

Status: Not yet enrolling

Conditions: Chronic Spontaneous Urticaria

Treatments: Diagnostic Test: Adenosine deaminase serum level; Diagnostic Test: IgE antibodies serum level

Study type: Observational

Funder types: Other

Identifiers

NCT05992987

Soh-Med-23-07-12MS

Details and patient eligibility

About

adenosine deaminase activity (ADA) has been reported to be elevated in various diseases such as psoriasis, acne and juvenile idiopathic arthritis. There is no previous studies that assessed ADA in chronic spontaneous urticaria (CSU) .

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients complaining of CSU and a group of age and sex-matched healthy controls (blood donors).

Exclusion criteria

• Pregnancy and lactation.
• Patients with systemic diseases, especially those with autoimmune diseases and infections.
• Patients with skin diseases.
• Patients on medications such as antibiotics, nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, anticonvulsants, penicillin, and combined oral contraceptives.

Trial design

90 participants in 2 patient groups

CSU group

Description:

Adult patients complaining of chronic spontaneous urticaria (CSU)

Treatment:

Diagnostic Test: Adenosine deaminase serum level

Diagnostic Test: IgE antibodies serum level

Control group

Description:

A group of age and sex-matched healthy controls (blood donors).

Treatment:

Diagnostic Test: Adenosine deaminase serum level

Diagnostic Test: IgE antibodies serum level