Assessment of Subsynovial Connective Tissue Thickness in Carpal Tunnel Syndrome

Catholic University (KU) of Leuven

Status

Completed

Conditions

Carpal Tunnel Syndrome

Treatments

Diagnostic Test: SSCT thickness measurement

Study type

Observational

Funder types

Other

Identifiers

NCT04491058

S63134

Details and patient eligibility

About

The general aim of this research is to gain insight in the role of SSCT in the etiology and progression of CTS. We hypothesize that (degenerative) damage of the SSCT occurs early on in the pathogenesis of CTS. Fibrotic damage to the SSCT will lead to altered morphology and biomechanical characteristics. This eventually may lead to damage of the median nerve. To examine the SSCT an ultrasound technique described by Van Doesburg et al. 2012 will be used First, the reliability of the US technique to characterize morphology of the SSCT will be investigated. Secondly, cross-sectional data will be collected in healthy subjects and CTS patients to provide descriptive parameters and to describe differences between patients and controls. In the final part a prospective study will be conducted to look at changes of SSCT thickness over time and after treatment.

Enrollment

92 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For CTS patients
Human adults, 18 years and older
Complaints compatible with CTS (Katz Hand Diagram[31] rating of 'classic', 'probable' or 'possible' or typical clinical signs)
Indication for electrodiagnostic testing
Informed consent to participate
For Healthy subjects
Human adults, 18 years and older
Negative electrodiagnostic testing and scoring 'unlikely' at Katz Hand diagram
Informed consent to participate

Exclusion criteria

Pregnancy
History of renal disease, diabetes, chemotherapy, tumors, other neurological diseases (e.g., polyneuropathy), thyroid disease
Problems of the upper limb, e.g., degenerative and inflammatory joint disease, gout, tendinopathy at the wrist, acute trauma of the upper limb