Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Breast Cancer

Konkuk University Medical Center

Status: Completed

Conditions: Breast Cancer

Treatments: Drug: propofol group; Drug: sevoflurane group

Study type: Interventional

Funder types: Other

Identifiers

NCT02567929

KUH1160086

Details and patient eligibility

About

Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence.

The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.

Full description

The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order.

1. immediate before anesthesia induction
2. postoperative 1 hours
3. postoperative 24 hours

Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay

Enrollment: 218 patients

Sex: Female

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient who was planned to undergo colon cancer surgery.

Exclusion criteria

• age < 20 years old
• history of hypersensitivity reaction in propofol or sevoflurane
• history of previous cancer
• patient with ongoing inflammation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Quadruple Blind

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218 participants in 2 patient groups

propofol group

Active Comparator group

Description:

The patient who anesthetized by using propofol.

Treatment:

Drug: propofol group

sevoflurane group

Active Comparator group

Description:

The patient who anesthetized by using propofol

Treatment:

Drug: sevoflurane group