Assessment of the Clinic-pathological Correlation of Basal Cell Carcinoma (CAC-CBC)

University Hospital of Bordeaux

Status: Completed

Conditions: Basal Cell Carcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT02825511

CHUBX 2014/18

Details and patient eligibility

About

Assessment of the concordance of the initial clinical and histological diagnosis and to explore its prognostic impact in terms of risk of recurrence.

Full description

The skin cancer is a major public health problem whose incidence is increasing due to the aging population. Among them, basal cell carcinoma (BCC) is a daily concern the dermatologist. The recommendation of good practice for the BCC of support has been established according to French agency methodology in 2004 : "Agence Nationale d'Accréditation et d'Evaluation en Santé" (ANAES). This classification is based on clinical and pathological use of sometimes mismatched terminology pretending to clinical reality with discrepancies between the clinical appearance and histology. On the other hand the simplified classification of recommendations has never been tested and validated on a large series of BCC. Probabilistic margins applied based on clinical assessment of clinical and pathological subtype, it seems interesting to evaluate the consistency of the initial clinical diagnosis and histological diagnosis and to explore its prognostic impact in terms of risk of recurrence.

This study could lead to improved clinical and pathological classification and allow amending the current recommendations of the surgical management of the BCC.

Enrollment: 2,738 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primitive BCC
• BCC clinically suspected or previously biopsied
• Supports conventional surgical or micrographic techniques.
• Patient able to sign a consent after reading the briefing note

Exclusion criteria

• Recurrent CBC
• prior medical treatment
• BCC assigned to another operator for removal
• Genodermatosis underlying (xeroderma pigmentosum - Gorlin syndrome)

Trial design

2,738 participants in 1 patient group

A cohort of basal cell carcinoma

Description:

A cohort of surgically treated BCC, primitive clinically suspected or previously biopsied on a 4-month period, an expected number of 3 200 cases. The management of the BCC will be consistent with current recommendations. BCC recurrence and those who received prior medical treatment will be excluded.