Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography

Isfahan University of Medical Sciences

Status and phase: Unknown; Phase 3

Conditions: Contrast Induced Nephropathy

Treatments: Drug: Atorvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT02113540

Grant number: 392172

Details and patient eligibility

About

As the effect of statin use before the angiography to prevent contrast induced nephropathy (CIN) is not well-known, the aim of the current study is to assess the effect of atorvastatin on prevention of CIN in patients undergoing coronary angiography.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• having chronic stable angina who were referred for coronary angiography
• non-pregnant female subjects
• no history of diabetes mellitus
• no history of renal failure
• no history of single kidney
• no history of cardiogenic shock
• no history of unstable angina
• no history of myocardial infarction
• no history of hypersensitivity to statins
• no history of previous intravascular contrast injection during one month before admission

Exclusion criteria

• glomerular filtration rate (GFR) <60
• cardiogenic shock

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 3 patient groups, including a placebo group

placebo group

Placebo Comparator group

Description:

taking atorvastatin like placebo 12 hours before the procedure

long term statin group

No Intervention group

Description:

taking atorvastatin for a long time before entering the study (their routine treatment)

preoperation statin group

Experimental group

Description:

taking atorvastatin 12 hours before the procedure

Treatment:

Drug: Atorvastatin