Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study

University of Sharjah

Status

Enrolling

Conditions

Endothelial Dysfunction

Periodontal Diseases

Treatments

Diagnostic Test: Salivary Nitric Oxide

Diagnostic Test: Assessment of pulse wave amplitude (PWA)

Study type

Observational

Funder types

Other

Identifiers

NCT05691426

REC-22-02-28-04-S

Details and patient eligibility

About

An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.

Enrollment

40 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Group 1: periodontally healthy subjects.
Group 2: patients with periodontitis stage III or IV and grades A,B or C.

Exclusion criteria

Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients with cardiovascular diseases including hypertension,recent myocardial infarction or unstable angina (within 3 months),congestive heart failure,valvular heart disease
Heavy smokers(>10 cigarettes per day),
Regular administration of drugs resulting in gingival hyperplasia,root planning in the past 6 months
Regular administration of drugs resulting in gingival hyperplasia (such as cyclosporine and phenytoin)
Recent antibiotic use (in the past 3 months)
Non-surgical periodontal therapy in the past 6 monthsp