Assessment of the Effect of Restriction on Alimentary AGE in Progression of Chronic Kidney Disease (CKD AGE)

Centre Hospitalier Saint Joseph Saint Luc de Lyon

Status: Not yet enrolling

Conditions: Chronic Kidney Disease stage3; Diet Habit; Chronic Kidney Disease Stage 3B; Chronic Kidney Disease Stage 3A (Disorder); Chronic Kidney Disease, Stage 3 (Moderate); Kidney Failure, Chronic

Treatments: Behavioral: High-AGE diet; Behavioral: Low-AGE diet

Study type: Interventional

Funder types: Other

Identifiers

NCT04827290

CKD AGE

Details and patient eligibility

About

Normal-protein and low-AGE through raw or rare proteins diet versus normal-protein and high-AGE diet in stage IIIa-b renal failure patients

Enrollment: 66 estimated patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a grade IIIA-B CKD (GFR with CKD-EPI ≥ 30 mL/min and < 60mL/min)
• Informed consent signed
• Aged 18 to 89 years

Exclusion criteria

• Protected adult
• Acute renal failure
• Patient already on a low-AGE diet (< 1kU AGE/day) following a dietetic consultation
• Current participation in another interventional research

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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66 participants in 2 patient groups

Normal-protein and low-AGE through raw or rare proteins diet

Experimental group

Description:

Normal-protein (0,8g/kg/day) and low-AGE through raw or rare proteins diet during 24 months

Treatment:

Behavioral: Low-AGE diet

Normal-protein and AGE-rich diet

Active Comparator group

Description:

Normal-protein (0,8g/kg/day) and high-AGE through overcooked proteins diet during 24 months

Treatment:

Behavioral: High-AGE diet