Assessment of the Efficacy of Topical Curcumin in Treatment of Oral Lichen Planus

Shaymaa Hussein Rafat Kotb

Status and phase: Completed; Phase 3

Conditions: Oral Lichen Planus

Treatments: Drug: topical triamcinolone acetonide combiend with topical curcumin; Drug: Topical Curcumin; Drug: topical triamcinolone acetonide

Study type: Interventional

Funder types: Other

Identifiers

NCT06605911

AUAREC20240004-15

Details and patient eligibility

About

to evaluate the therapeutic impact of curcumin as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus.

Full description

Background: Oral lichen planus (OLP) is a chronic inflammatory disorder affecting the mucous membranes, believed to be an immune-mediated condition. Its persisting nature can lead to extended discomfort for those affected. The primary symptoms are pain and a burning sensation, with a potential risk of malignancy if not properly managed, necessitating lifelong clinical monitoring. Presently, OLP is considered a significant challenge due to the absence of a definitive cure.

Patients & patients: Thirty patients with oral lichen planus were divided into three groups, 10 patients each: Group A: ten patients with OLP were received topical triamcinolone acetonide. Group B: ten patients with OLP were received topical curcumin. Group C: ten patients with oral lichen planus were received topical triamcinolone acetonide combiend with topical curcumin. For six weeks. Each patient was examined at baseline,1 and 3months of therapy. Pain was scored using the visual analogue scale. Salivary level of interleukin 1 were estimated at baseline,1and 3 months' evaluation periods.

Enrollment: 30 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of OLP

Exclusion criteria

• Any systemic autoimmune disease
• Any current use of anticoagulant or antiplatelet agents (curcumin has inhibitory effects on platelet aggregations).
• Any topical, local or systemic corticosteroids therapy during the past 3 months.
• lichenoid reaction from medications.
• Pregnant or lactation women.
• smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

Topical triamcinolone acetonide

Experimental group

Description:

Group I

Treatment:

Drug: topical triamcinolone acetonide

Topical curcumin

Experimental group

Description:

Group II

Treatment:

Drug: Topical Curcumin

Topical triamcinolone acetonide combiend with topical curcumin

Active Comparator group

Description:

Group III

Treatment:

Drug: topical triamcinolone acetonide combiend with topical curcumin