Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery

University of Liege

Status: Unknown

Conditions: Adult Cardiac Surgery

Treatments: Device: External Pacing Box

Study type: Interventional

Funder types: Other

Identifiers

NCT02407574

FFR2015

Details and patient eligibility

About

The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium. After complete weaning from CPB, several pressure-loops of the LV will be recorded at different levels of preload using transoesophageal echo, invasive blood pressure monitoring. The preload will be manipulated by adding fluid from the CPB reservoir or draining fluid into the CPB reservoir.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CABG only surgery
• Preopeartive LVEF ≥ 53 %
• Use of epicardial pacing wires to assist CPB weaning

Exclusion criteria

• Contra-indication to TEE
• AV block at the time of CPB weaning
• Sinus rhythm less than 50 or more than 90 BPM after CPB weaning.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Spontaneous rhythm first

Experimental group

Description:

Stepwise preload increase by repeated administration of 100 mL of fluid during spontaneous rhythm and then stepwise preload reduction by repeated drainage of 100 mL of fluid during atrial pacing.

Treatment:

Device: External Pacing Box

Atrial pacing first

Experimental group

Description:

Stepwise preload increase by repeated administration of 100 mL of fluid during atrial pacing and then stepwise preload reduction by repeated drainage of 100 mL of fluid during spontaneous rhythm.

Treatment:

Device: External Pacing Box