Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage

Neuromed IRCCS

Status: Unknown

Conditions: Left Ventricular Diastolic Dysfunction

Treatments: Other: No interventions

Study type: Observational

Funder types: Other

Identifiers

NCT04549298

LMB09

Details and patient eligibility

About

Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures. Currently, it is possible to classify it in 3 grades: grade 1 with normal filling pressures, grade 2 and grade 3 with high pressures. Diastolic dysfunction is closely associated with several risk factors such as hypertension, diabetes, and obesity, as well as the risk of heart failure, cardiovascular events, and death. In the field of cerebrovascular diseases, however, diastolic dysfunction is still being researched. Thus, this study aims to: 1) evaluate the white matter hyperintensities volume in association with the increase of diastolic dysfunction and filling pressures 2) evaluate the possible association with carotid atherosclerosis in case of brain damage caused by dysfunction diastolic 3) understand the mechanism of damage caused by left ventricular diastolic dysfunction on the cerebrovascular system. In order to do this, this study proposes to evaluate in a cohort of patients, between 35 and 65 years, the possible association of diastolic dysfunction with lesions on the cerebrovascular system in a future view of new marker of brain damage and new modifiable risk factor.

Enrollment: 88 estimated patients

Sex: All

Ages: 35 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 35 and ≤ 65 years
• written informed consent

Exclusion criteria

• previous stroke or TIA
• arrhythmia or severe cardiac disease
• renal disease
• psychiatric disease
• neurological or neurodegenerative disease
• dementia
• previous carotid artery stenting or carotid surgery
• inability to be subjected MRI analysis

Trial design

88 participants in 2 patient groups

Patients with grade 2 and 3 LV diastolic dysfunction

Description:

Patients with high filling pressure

Treatment:

Other: No interventions

Patients with normal and grade 1 LV diastolic dysfunction

Description:

Patients with normal filling pressure

Treatment:

Other: No interventions