Assessment of Voriconazole Penetration Into the Brain by Fluorine-Magnetic Resonance Spectroscopy

Pfizer

Status and phase: Completed; Phase 1

Conditions: Fungal Infection

Treatments: Drug: Voriconazole

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00136968

A1501060

Details and patient eligibility

About

The purpose of this study is to determine the amount of voriconazole in the brain by fluorine-magnetic resonance spectroscopy (MRS) and to compare brain levels to plasma levels.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteers 18-55 years of age

Exclusion criteria

• Subjects with any condition affecting drug absorption
• Subjects with a positive urine drug screen