Assessment of VZV-specific ELISPOT Assay for Predicting VZV Infection in Kidney Transplant Recipients (AVE-KT)

Asan Medical Center

Status: Terminated

Conditions: Kidney Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT02081729

2014-0107

Details and patient eligibility

About

VZV is one of the important opportunistic infection in transplant recipients.Until now, there is no laboratory method to stratify the risk of VZV reactivation after solid organ transplantation. Theoretically, VZV-specific cell-mediate immune response before solid organ transplantation will further categorize the patients into high or low risk of VZV development after solid organ transplantation. The investigators thus evaluate the usefulness of VZV-specific ELISPOT assay in kidney transplant candidates to predict the development of VZV infection after kidney transplantation.

Full description

We will develop VZV-specific ELISPOT assay, then perform this assay before transplantation. We will evaluate whether this assay will predict zoster reactivation after transplantation.

Enrollment: 10 patients

Sex: All

Ages: 16 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 16 years or more
• agree with written informed consent
• WBC count 2000/uL or more

Exclusion criteria

• no exclusion criteria

Trial design

10 participants in 2 patient groups

high VZV ELISPOT results

Description:

high spot counts in ELISPOT

low VZV ELISPOT results

Description:

low spot counts in ELISPOT