Assessment the Cancer Risk of Indeterminate Thyroid Nodules Through Integration of Clinical, Ultrasonographic and Multiomic Features (THYOMICS)

University of Cagliari

Status: Not yet enrolling

Conditions: Thyroid Nodule; Thyroid Cancer

Treatments: Diagnostic Test: Multiomic analyses of blood and surgical specimens

Study type: Observational

Funder types: Other

Identifiers

NCT05428371

THYOMICS

Details and patient eligibility

About

Indeterminate thyroid nodules have a mild risk of malignancy (15-30%). The aim of our study is to individuate new biomarkers of thyroid carcinoma through multiomic analyses of blood samples and of specimen samples of patients with indeterminate thyroid nodules.

Enrollment: 256 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with indeterminate thyroid nodules (Class III and Class IV according to Bethesda Classification of thyroid nodules)

Exclusion criteria

• Patients with concomitant thyroid nodules of Bethesda Class V or Class VI
• Patients with preoperative diagnosis of lymph node metastases of central or lateral neck compartment
• Patients with distant metastases

Trial design

256 participants in 2 patient groups

Thyroid carcinoma

Description:

Patients with indeterminate thyroid nodule and pathological diagnosis of thyroid carcinoma

Treatment:

Diagnostic Test: Multiomic analyses of blood and surgical specimens

Follicular adenoma

Description:

Patients with indeterminate thyroid nodule and pathological diagnosis of follicular adenoma

Treatment:

Diagnostic Test: Multiomic analyses of blood and surgical specimens