Assessment Vitamin D Analogues Intake Pathways on the Proteins Which Involved in Metabolic Rate in Obese Subjects

T

Tehran University of Medical Sciences

Status

Unknown

Conditions

Obesity

Treatments

Dietary Supplement: Placebo
Dietary Supplement: Vitamin D analogue

Study type

Interventional

Funder types

Other

Identifiers

NCT01894295
91-03-27-18831

Details and patient eligibility

About

The aim of this double blind clinical trial study is to investigate whether alphacalcidol treatment in obese subjects can affect the resting metabolic rate. Moreover, the investigators will evaluate the pathways of Nesfatin-1, Peroxisome proliferator-activated receptor gamma (PPARγ) and eroxisome proliferator-activated receptor- coactivator-1 α (PGC1α) protein which may lead to change in metabic rate following treatment with either alphacalcidol or placebo.

Enrollment

96 estimated patients

Sex

All

Ages

22 to 52 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 22-52 years Body mass index equal or more than 30

Exclusion criteria

Acute or chronic inflammatory disease History of hypertension Alcohol or drug abuse History of any condition affecting inflammatory markers Thyroid diseases Malignancies Current smoking Diabetes mellitus Sustained hypertension Heart failure Acute or chronic infections Hepatic or renal diseases Use of PPARγ agonist drug

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

96 participants in 2 patient groups, including a placebo group

Vitamin D analogue
Experimental group
Description:
1-α hydroxyvitamin D3; dose 0.25, 0.5 and 1 microgram.
Treatment:
Dietary Supplement: Vitamin D analogue
Placebo
Placebo Comparator group
Description:
Corn oil pearl Capsules 1 gram
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

1

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Central trial contact

Khadijeh Mirzaei, MS; Mahmoud Jalali, Phd

Data sourced from clinicaltrials.gov

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