Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure

Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche

Status: Completed

Conditions: Chronic Respiratory Failure

Treatments: Procedure: respiratory settings

Study type: Interventional

Funder types: Other

Identifiers

NCT00189527

2000-2

Details and patient eligibility

About

Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode.

The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Full description

The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic respiratory failure
• Clinical symptoms of chronic alveolar hypoventilation
• PaCO2 ≥ 45 mmHg in case of restrictive pulmonary disorder or PaCO2 ≥ 55 mmHg in case or obstructive pulmonary disorder

Exclusion criteria

• Clinical exacerbation during the three previous weeks
• Previous treatment by domiciliary non invasive ventilation
• Previous treatment by non invasive ventilation for acute respiratory failure during the 3 previous months
• Bronchiectasis
• Duchenne muscular dystrophy
• Amyotrophic lateral sclerosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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100 participants in 2 patient groups

respiratory support

Experimental group

Description:

a mode of ventilation in comparison

Treatment:

Procedure: respiratory settings

Assist Control

Active Comparator group

Description:

an other mode of ventilation in comparison

Treatment:

Procedure: respiratory settings