Assisted Hatching Versus Endometrial Scratch in Recurrent Implantation Failure

K

Kasr El Aini Hospital

Status

Unknown

Conditions

Recurrent Implantation Failure

Treatments

Procedure: endometrial scratch
Procedure: controlled ovarian hyperstimulation
Procedure: assisted hatching

Study type

Interventional

Funder types

Other

Identifiers

NCT02752568
ivfobgyn

Details and patient eligibility

About

300 recurrent implantation failure patients will be alternatively assigned to assisted hatching , endometrial scratch , and no treatment ,100 patients in each group

Full description

Group 1 consists of 100 patients will undergo endometrial scratch followed by controlled ovarian hyperstimulation Group 2 consists of 100 patients will undergo controlled ovarian hyperstimulation& assisted hatching Group 3 consists of 100 patients will undergo controlled ovarian hyperstimulation

Enrollment

300 estimated patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • recurrent implantation failure
  • normal uterine cavity by transvaginal ultrasound

Exclusion criteria

  • endometrial polyp or fibroid distorting the endometrium
  • hydrosalpinx
  • preimplantation genetic diagnosis
  • severe male factor

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

None (Open label)

300 participants in 3 patient groups

Endometrial scratch group
Active Comparator group
Description:
endometrial scratch controlled ovarian hyperstimulation
Treatment:
Procedure: controlled ovarian hyperstimulation
Procedure: endometrial scratch
Assisted hatching group
Active Comparator group
Description:
assisted hatching controlled ovarian hyperstimulation
Treatment:
Procedure: assisted hatching
Procedure: controlled ovarian hyperstimulation
ovarian stimulation only group
Sham Comparator group
Description:
controlled ovarian hyperstimulation
Treatment:
Procedure: controlled ovarian hyperstimulation

Trial contacts and locations

0

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Central trial contact

suzy abdelaziz, lecturer

Data sourced from clinicaltrials.gov

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