Assisted Hatching Versus Endometrial Scratch in Recurrent Implantation Failure

Kasr El Aini Hospital

Status: Unknown

Conditions: Recurrent Implantation Failure

Treatments: Procedure: endometrial scratch; Procedure: controlled ovarian hyperstimulation; Procedure: assisted hatching

Study type: Interventional

Funder types: Other

Identifiers

NCT02752568

ivfobgyn

Details and patient eligibility

About

300 recurrent implantation failure patients will be alternatively assigned to assisted hatching , endometrial scratch , and no treatment ,100 patients in each group

Full description

Group 1 consists of 100 patients will undergo endometrial scratch followed by controlled ovarian hyperstimulation Group 2 consists of 100 patients will undergo controlled ovarian hyperstimulation& assisted hatching Group 3 consists of 100 patients will undergo controlled ovarian hyperstimulation

Enrollment: 300 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• recurrent implantation failure
• normal uterine cavity by transvaginal ultrasound

Exclusion criteria

• endometrial polyp or fibroid distorting the endometrium
• hydrosalpinx
• preimplantation genetic diagnosis
• severe male factor

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

---

300 participants in 3 patient groups

Endometrial scratch group

Active Comparator group

Description:

endometrial scratch controlled ovarian hyperstimulation

Treatment:

Procedure: controlled ovarian hyperstimulation

Procedure: endometrial scratch

Assisted hatching group

Active Comparator group

Description:

assisted hatching controlled ovarian hyperstimulation

Treatment:

Procedure: controlled ovarian hyperstimulation

Procedure: assisted hatching

ovarian stimulation only group

Sham Comparator group

Description:

controlled ovarian hyperstimulation

Treatment:

Procedure: controlled ovarian hyperstimulation