Association Between a Biological Pattern of Dysregulation of the HPA Axis and Mental Disorders in Children Exposed to Early Life Stress (ESASP)

Regional University Hospital Center (CHRU)

Status: Terminated

Conditions: Mental Disorder, Child

Treatments: Behavioral: Mini Kid II

Study type: Interventional

Funder types: Other

Identifiers

NCT04363112

29BRC20.0056

Details and patient eligibility

About

The purpose of this study is to demonstrate an association between a biological pattern of dysregulation of the HPA axis and mental disorders in children exposed to early life stress.

Full description

The purpose of this study is to demonstrate an association between a biological pattern of dysregulation of the HPA axis and mental disorders in children exposed to early life stress.

Cortisol secretion lead to define two groups : pathologic versus normal cortisol secretion.

Mental disorders is evaluate with Mini-Kids II (a mental health questionary) and lead to define two groups : mental disorders versus no mental disorders

Enrollment: 8 patients

Sex: All

Ages: 8 to 10 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 8 to over 10 years
• To be entrust to ASE of Finistère in stable environment (the same place of residence since 6 months or more)
• French speaking
• Oral consent by children
• Informed and signed consent by tenured of parent authority

Exclusion criteria

• Don't want to participate
• To have chronic neurologic or endocrinal pathology or don't have access to verbal language.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

study with just one arm

Other group

Description:

All of participants are in this arm. Mini Kid II and CBCL score are administered between day 3 and 7. Moreover, salivary test will be remove to evaluate cortisol secretion, 4 time per day during 2 consecutive days. Psychologic aftercare will be propose if children have psychologic troubles (results of Mini Kid II)

Treatment:

Behavioral: Mini Kid II