Association Between Administration of Dexmedetomidine and Postoperative Mortality in Hospitals

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: In-hospital Mortality

Treatments: Drug: Dexmedetomidine

Study type: Observational

Funder types: Other

Identifiers

NCT06248346

KY20192045-C-1

Details and patient eligibility

About

The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals.

The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.

Enrollment: 518,043 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients (aged ≥18 years)
• undergo general anaesthesia with propofol
• from January 1, 2014 to June 30, 2018

Exclusion criteria

• patients undergoing intervention procedures under monitored anaesthesia care (MAC)
• patients undergoing minor procedures under local or regional anaesthesia

Trial design

518,043 participants in 2 patient groups

dexmedetomidine

Description:

dexmedetomidine group: abbreviated for dexmedetomidine group, refers to the group with intraoperative administration of dexmedetomidine adjunct to propofol

Treatment:

Drug: Dexmedetomidine

non-dexmedetomidine

Description:

non-dexmedetomidine group: abbreviated for non-dexmedetomidine group, refers to the group without intraoperative administration of dexmedetomidine adjunct to propofol