Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation (AAAF)

Zhejiang University

Status: Enrolling

Conditions: Atrial Fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT05524142

2022-0404

Details and patient eligibility

About

This study is a case-control study. In this study, 2ml of vein blood samples were collected from patients with atrial fibrillation undergoing radiofrequency ablation and those in the control group who underwent electrophysiological examination alone and confirmed no arrhythmia. The purpose of this study is to identify the relationship between the aldehyde dehydrogenase 2 (ALDH2) gene polymorphism and susceptibility to atrial fibrillation, and to explore the relationship between the genotype of ALDH2 SNP and the prognosis of patients with atrial fibrillation undergoing radiofrequency ablation.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed informed consent;

  • Age 18-85 years old, gender is not limited; ③ Case group: patients with clinical diagnosis of atrial fibrillation who underwent radiofrequency ablation; control group: patients with no arrhythmia confirmed by electrophysiological examination; ④ Able to communicate well with investigators and comply with the entire trial requirements.

Exclusion criteria

• Those who cannot understand or refuse to sign the informed consent or follow-up; ②Pregnant women, mentally retarded, mental/cognitive insufficiency and other possible vulnerable groups

Trial design

200 participants in 2 patient groups

Atrial fibrillation

Description:

Patients with atrial fibrillation underwent radiofrequency ablation.

Control

Description:

Patients underwent electrophysiological examination alone and were confirmed no arrhythmia.