Association Between Arterial Wall Uptake of Fluorodeoxyglucose on PET Imaging and sRAGE

Korea University

Status: Completed

Conditions: sRAGE Level; SUV and TBR Levels in FDG PET

Study type: Observational

Funder types: Other

Identifiers

NCT01021514

PET(RAGE)

Details and patient eligibility

About

Arteriosclerosis is a dynamic inflammatory disorder. Recently, FDG-PET CT is emerging diagnostic tool of non-invasive technique to detect vulnerable atherosclerotic plaque. And there are arising evidence that sRAGE(soluble Receptor for Advanced glycation End Product) is correlated with metabolic risk. So the investigators will investigate association between sRAGE and FDG-PET uptake in large artery in healthy patient.

Enrollment: 82 patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis od type 2 DM

Exclusion criteria

• Type 1 DM
• Gestational Diabetes
• Severe Liver or Renal disease
• Diagnosis of cancer
• Trauma
• Acute infection or inflammatory disease
• Acute vasculitis or history of vasculitis
• Pregnant or Lactating women
• Dyslipidemia(active state)
• Cardiovascular disease or history of CVD
• Chronic obstructive pulmonary disease
• Any patient by judge of investigator

Trial design

82 participants in 2 patient groups

Type 2 DM, Healthy control

Description:

Type 2 DM patients are treating in the Diabetic Clinic of Korea university Guro hospital, and their age- and sex-matched healthy controls are underwent a routine health checkup at Korea university Guro hospital.

Type 2 DM, Heatlhy control