Association Between BMI and COVID-19 (BMI-SARS-CoV-2)

University Hospital, Lille

Status

Completed

Conditions

SARS-CoV 2

Treatments

Other: Patients admitted to Intensive Care Unit with SARS-CoV2

Study type

Observational

Funder types

Other

Identifiers

NCT04391738

DEC20-095

Details and patient eligibility

About

This study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. Collating data from a large volume of patients with COVID-19 admitted in ICU across multiple international sites will enable investigation of whether obesity is a risk factor for complicated from of SARS-CoV-2 in adult patients and whether this association is independent of other cardiometabolic risk factors.

Full description

The COVID-19 pandemic is characterized by a high frequency of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), who often require invasive mechanical ventilation (IMV). Body mass index (BMI) was however rarely mentioned in early clinical reports.

Disease severity gradually increased with body mass index (BMI) categories among patients admitted in intensive care unit (ICU) for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the need for invasive mechanical ventilation (IMV), reaching 85% in patients with class II or III obesity ( BMI > 35 kg/m2).

In summary, there is an urgent need for more evidence on the specific role played by obesity in the development of COVID-19 complications, and more particularly of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Enrollment

1,200 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Participant is aged 18 years or over
Has been admitted to ICU with COVID-19 disease.
COVID-19 disease has been confirmed by PCR for SARS-CoV-2
Height and weight or BMI on admission has been recorded
Data has been collected in an ethical manner as part of a national database or clinical auditing process approved by the local institution or collaboration

Exclusion criteria

-There are no exclusion criteria