Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Moscow Clinical Scientific Center

Status: Completed

Conditions: Astrogliosis; Postoperative Delirium; Postoperative Cognitive Dysfunction

Treatments: Diagnostic Test: Glial fibrillary acidic protein

Study type: Observational

Funder types: Other

Identifiers

NCT03683537

MKNC 02/2018

Details and patient eligibility

About

Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.

Enrollment: 30 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with different diseases, who require prolonged laparoscopy or open surgery
• Age more than 60
• ASA I-III
• Informed consent to participate in the study

Exclusion criteria

• ASA IV-V
• Severe neurodegenerative or psychological diseases

Trial design

30 participants in 2 patient groups

Delayed Neurocognitive decline

Description:

Patients in whom there is Delayed Neurocognitive Recovery (DNR) after surgery, based on neuropsychological tests or clinically. DNR is defined as follow: 1)decrease of scores of neuropsychological test scores for more than 1 standard deviation (SD) of these tests; 2)clinically - inability of patient to perform test after surgery because of neurocognitive impairment.

Treatment:

Diagnostic Test: Glial fibrillary acidic protein

Normal postop neurocognitive function

Description:

Patients in whom there is no clinical signs of DNR, defined as in previous group.

Treatment:

Diagnostic Test: Glial fibrillary acidic protein