Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome

Shandong University

Status: Completed

Conditions: Mucosal Microbiome; Hyperplasia; Colorectal Inflammation; Colorectal Neoplasia

Treatments: Other: the mucosal microbiome in the biopsy specimen was analysed

Study type: Observational

Funder types: Other

Identifiers

NCT02063919

2014SDU-QILU-G01

Details and patient eligibility

About

The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.

Full description

The gut microbiome plays a pivotal role in the intestinal pathophysiology. The mucosal microbiome is in the front face of microbiome-host cross-talk. Confocal laser endomicroscopy (CLE) can provide realtime mucosal images during ongoing endoscopy. We hypothesized that the mucosal pattern, here evaluated by endomicroscopy, may constitute specific microbiome niches and participate the evolvement of the mucosal microbiome.

Enrollment: 45 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years old ≤ age < 80 years old
• Scheduled for colonoscopy in Qilu Hospital

Exclusion criteria

• antibiotic usage within 2 months
• probiotic or prebiotic usage within 2 months
• ascites
• jaundice
• liver cirrhosis
• impaired renal function
• coagulopathy
• fever
• pregnancy
• breastfeeding
• inability to provide informed consent
• known allergy to fluorescein sodium

Trial design

45 participants in 1 patient group

endomicroscopy

Treatment:

Other: the mucosal microbiome in the biopsy specimen was analysed