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Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome

S

Shandong University

Status

Completed

Conditions

Mucosal Microbiome
Hyperplasia
Colorectal Inflammation
Colorectal Neoplasia

Treatments

Other: the mucosal microbiome in the biopsy specimen was analysed

Study type

Observational

Funder types

Other

Identifiers

NCT02063919
2014SDU-QILU-G01

Details and patient eligibility

About

The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.

Full description

The gut microbiome plays a pivotal role in the intestinal pathophysiology. The mucosal microbiome is in the front face of microbiome-host cross-talk. Confocal laser endomicroscopy (CLE) can provide realtime mucosal images during ongoing endoscopy. We hypothesized that the mucosal pattern, here evaluated by endomicroscopy, may constitute specific microbiome niches and participate the evolvement of the mucosal microbiome.

Enrollment

45 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 18 years old ≤ age < 80 years old
  • Scheduled for colonoscopy in Qilu Hospital

Exclusion criteria

  • antibiotic usage within 2 months
  • probiotic or prebiotic usage within 2 months
  • ascites
  • jaundice
  • liver cirrhosis
  • impaired renal function
  • coagulopathy
  • fever
  • pregnancy
  • breastfeeding
  • inability to provide informed consent
  • known allergy to fluorescein sodium

Trial design

45 participants in 1 patient group

endomicroscopy
Treatment:
Other: the mucosal microbiome in the biopsy specimen was analysed

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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