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Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome

S

Shandong University

Status

Unknown

Conditions

Mucosal Microbiome
Intestinal Metaplasia
Gastric Neoplasia
H.Pylori

Treatments

Other: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing

Study type

Observational

Funder types

Other

Identifiers

NCT02063932
2014SDU-QILU-G02

Details and patient eligibility

About

There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.

Full description

The gastric mucosal microbiome plays a pivotal role in a series of diseases, such as the H.pylori infection. We hypothesized that mucosal patterns, here visualized by confocal endomicroscopy, may constitute specific microbiome niches.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled for gastroendoscopy examination
  • Aged between 18 and 80 years old

Exclusion criteria

  • Antibiotic, probiotic or prebiotic usage within 2months
  • Esophageal, gastric or duodenal cancer or other malignancy
  • History of upper GI tract surgery
  • Coagulopathy or bleeding disorders
  • Allergy to fluorescein sodium
  • Pregnant or breast-feeding (for females)
  • Impaired renal function

Trial design

60 participants in 1 patient group

endomicroscopy
Treatment:
Other: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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