Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome

Shandong University

Status: Unknown

Conditions: Mucosal Microbiome; Intestinal Metaplasia; Gastric Neoplasia; H.Pylori

Treatments: Other: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing

Study type: Observational

Funder types: Other

Identifiers

NCT02063932

2014SDU-QILU-G02

Details and patient eligibility

About

There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.

Full description

The gastric mucosal microbiome plays a pivotal role in a series of diseases, such as the H.pylori infection. We hypothesized that mucosal patterns, here visualized by confocal endomicroscopy, may constitute specific microbiome niches.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for gastroendoscopy examination
• Aged between 18 and 80 years old

Exclusion criteria

• Antibiotic, probiotic or prebiotic usage within 2months
• Esophageal, gastric or duodenal cancer or other malignancy
• History of upper GI tract surgery
• Coagulopathy or bleeding disorders
• Allergy to fluorescein sodium
• Pregnant or breast-feeding (for females)
• Impaired renal function

Trial design

60 participants in 1 patient group

endomicroscopy

Treatment:

Other: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing